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Obstetric dating and assessment

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Accurate determination of gestational age is fundamental to obstetric care and is important in a variety of situations.

For example, antenatal test interpretation may be dependent on gestational age.

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Genetic screening for Down syndrome (trisomy 21) and trisomy 18, the national standard in the United States, is rapidly evolving away from the AFP-Quad screen for Down syndrome, done typically in the second trimester at 16–18 weeks. Ultrasound is also used for detecting congenital anomalies (or other foetal anomalies) and determining the biophysical profiles (BPP), which are generally easier to detect in the second trimester when the foetal structures are larger and more developed.

The cost is higher than an "AFP-quad" screen due to the ultrasound and second blood test, but it is quoted to have a 93% pick up rate as opposed to 88% for the standard AFP/QS.

R for First And Second Trimester Early Results) can be done at 10 plus weeks to 13 plus weeks with an ultrasound of the fetal neck (thick skin is bad) and two chemicals (analytes) PAPP-A and βHCG (pregnancy hormone level itself). A second blood screen at 15 to 20 weeks refines the risk more accurately.

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Gestational age, synonymous with menstrual age, is defined in weeks beginning from the first day of the last menstrual period (LMP) prior to conception.